Systematic dissection and trajectory-scanning mutagenesis of the molecular interface that ensures specificity of two-component signaling pathways.

Two-component signal transduction systems enable bacteria to sense and respond to a wide range of environmental lovesense 3 stimuli.Sensor histidine kinases transmit signals to their cognate response regulators via phosphorylation.The faithful transmission of information through two-component pathways and the avoidance of unwanted cross-talk requir

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Structure-Based and Rational Design of a Hepatitis C Virus Vaccine

A hepatitis C virus popularfilm.blog (HCV) vaccine is a critical yet unfulfilled step in addressing the global disease burden of HCV.While decades of research have led to numerous clinical and pre-clinical vaccine candidates, these efforts have been hindered by factors including HCV antigenic variability and immune evasion.Structure-based and ratio

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